| Wu Ding-chang |
1948-05 to 1948-12 |
| Wu Zhong-xin |
1948-12 to 1949-02 |
| Weng Wen-hao |
1949-02 to 1949-05 |
| Qiu Chang-wei |
1949-06-26 to 1950-03 |
| Wang Shi-jie |
1950-03-23 to 1953-11-16 |
| Xu Jing-zhi (Concurrently serving as Acting Secretary-General to the President) |
1953-11-17 to 1954-05-17 |
| Zhang Qun |
1954-05-18 to 1972-05-28 |
| Zheng Yan-fen |
1972-05-29 to 1978-05-19 |
| Tsiang Yen-si |
1978-05-20 to 1978-12-19 |
| Ma Chi-chuang |
1978-12-20 to 1984-05-31 |
| Shen Chang-huan |
1984-06-01 to 1988-10-16 |
| Li Yuan-zu |
1988-10-18 to 1990-05-19 |
| Tsiang Yen-si |
1990-05-20 to 1994-12-12 |
| Wu Poh-hsiung |
1994-12-19 to 1996-01-25 |
| The ROC (Taiwan) Office of the President Organization Act was amended and became effective on January 26, 1996. |
| Wu Poh-hsiung |
1996-01-26 to 1996-08-04 |
| Huang Kun-huei |
1996-08-05 to 1999-11-17 |
| John H. Chang |
1999-11-18 to 1999-12-22 |
| Ding Mou-shih |
1999-12-23 to 2000-05-19 |
| Chang Chun-hsiung |
2000-05-20 to 2000-07-31 |
| Chen Che-nan (Acting Secretary-General to the President) |
2000-08-01 to 2000-10-05 |
| Yu Shyi-kun |
2000-10-06 to 2002-01-31 |
| Chen Shih-meng |
2002-02-01 to 2003-02-05 |
| Chiou I-jen |
2003-02-06 to 2004-05-19 |
| Su Tseng-chang |
2004-05-20 to 2005-01-31 |
| Yu Shyi-kun |
2005-02-01 to 2005-12-16 |
| Ma Yung-chen (Acting Secretary-General to the President) |
2005-12-17 to 2006-01-24 |
| Chen Tan-sun |
2006-01-25 to 2007-02-06 |
| Chiou I-jen |
2007-02-07 to 2007-05-20 |
| Cho Jung-tai (Acting Secretary-General to the President) |
2007-05-21 to 2007-08-19 |
| Yeh Chu-lan |
2007-08-20 to 2008-03-26 |
| Chen Tan-sun |
2008-03-27 to 2008-05-19 |
| Chan Chuen-po |
2008-05-20 to 2009-09-09 |
| Liouyi Liao |
2009-09-10 to 2011-01-30 |
| Wu Jin-lin |
2011-01-31 to 2012-02-05 |
| Tseng Yung-chuan |
2012-02-06 to 2012-09-26 |
| Timothy C. T. YANG |
2012-09-27 to 2015-02-11 |
| Tseng Yung-chuan |
2015-02-12 to 2016-05-19 |
| Lin Bih-jaw |
2016-05-20 to 2016-10-19 |
| Liu Chien-sin (Acting Secretary-General to the President) |
2016-10-20 to 2017-05-21 |
| Jaushieh Joseph Wu |
2017-05-22 to 2018-02-25 |
| Liu Chien-sin (Acting Secretary-General to the President) |
2018-02-26 to 2018-04-20 |
| Chen Chu |
2018-04-21 to 2020-05-19 |
| Su Jia-chyuan |
2020-05-20 to 2020-08-02 |
| Liu Chien-sin (Acting Secretary-General to the President) |
2020-08-03 to 2020-08-03 |
| David Tawei Lee |
2020-08-04 to 2023-01-30 |
| Lin Chia-lung |
2023-01-31 to 2024-05-19 |
| Pan Men-an |
2024-05-20 to current |